Takayasu arteritis (TA) is a rare Granulomatous Panarthritis, characterized by stenosis or obliteration of large and medium-sized arteries, such as the aorta. The onset of symptoms tends to lead to a delay in diagnosis that can range from months to years, during which time vascular disease may initiate and progress to become symptomatic. In this context, TA may present with various uncommon cardiovascular complications such as dilated cardiomyopathy, valvulitis, and Myocarditis. Herein, we report on a 29-year-old female who initially presented with active Myocarditis and was later incidentally diagnosed with TA.

Background: Takayasu arteritis (TA) or giant cell vasculitis is the third common vasculitis after Henoch-Schoenline purpura and Kawasaki disease in children. This vasculitis usually affects large vessels and is more common in females during the childhood. Aim of this report is to present three Iranian children (two boys, one girl) with TA.Case Presentation: Mean age of our Cases on admission was 10 years. Patients most commonly presented with episodes of systemic symptoms including, fever, headache, increased arterial blood pressure in one limb and convulsion. Other related symptoms were myalgia, limb pain, chest pain, and abdominal pain. Supra sternal, and abdominal bruit was noted in all patients. Angiography was performed in all Cases. This revealed stenosis of the left subclavian artery and common carotid artery in one patient, generalized aortitis in one Case and stenotic right renal artery in one patient. One boy was diagnosed as having systemic onset of juvenile idiopathic arthritis. One Case was referred with hand pain and headache, and one Case for control of hypertension. Follow-up ranged from 2 to 7 years since diagnosis. All patients were I treated with prednisone, azathioprine, aspirin, and antihypertensive drugs. Each patient received either methotrexate, or hydroxychloroquine or mycofenolate mofetil.Conclusion: Although TA is uncommon before 10th year of life, it should be considered in patients presenting with hypertension and systemic symptoms such as fever, limb pain and pulseless limb.

Neurological manifestation may complicate Takayasu arteritis (TA). A 23-year-old girl with sudden onset of vision loss was admitted to hospital. Her brain MRI showed abnormal T2-signal hyperintensity and visual evoked potential revealed prolonged P100 latency. Consequently, optic neuritis was diagnosed. A review on history of dizziness, falling, and weak pulses of upper extremities led to more investigation. Angiography revealed a total occlusion of right and left carotids, left vertebral arteries, aneurismal dilatation of innominate artery and critical stenosis of right vertebral artery. Following diagnosis of TA, stenting of right vertebral artery was done, but she passed away because of subarachnoid hemorrhage.

Background: Takayasu’, s arteritis (TAK) is an idiopathic large-vessel vasculitis. Sensori-neural hearing loss is a rare complication in patients with TAK. In this study, we report an adult woman with hearing loss associated with TAK who underwent cochlear implantation (CI). The Case: The Case was a 28-year-old hearing-impaired woman with TAK who underwent uni-lateral CI. The surgery improved the patient’, s speech perception and perceived sound quality. However, her auditory and speech performances changed over time. Conclusion: The present Case report highlights the importance of monitoring auditory and spe-ech performance of CI patients with TAK.

Takayasu’ s arteritis (TA) is a rare Case of Granulomatous arteritis which mainly involves the aorta and its large branches. Although arterial hypertension is the most common feature of the disease in both adults and children, patients with TA may present with numerous clinical manifestations. Our patient was a 45-year-old woman, known to have hypertension from 3 years earlier following assessments made for severe headache. One year after the diagnosis of hypertension, she developed a left-sided lower motor neuron facial palsy, which was treated with oral corticosteroids (Prednisolone). Notably, the patient's headache was relieved after she took corticosteroid therapy. Transthoracic echocardiography revealed severe aortic insufficiency and aneurysmal changes in the ascending aorta, and she was referred to our center for further evaluation. In multi-slice computed-tomography angiography, significant long stenosis of the left subclavian artery was seen and the diameter of the ascending aorta was 50 mm. The patient underwent the Bentall operation. The pathologic examination of the aortic wall specimen was compatible with giant cell aortitis and more in favor of TA with the ascending aortic aneurysm. At 6months' follow-up, the patient was in good condition and had almost recovered from facial palsy.